Endocrine Abstracts

Adult GH deficiency (AGHD) is a common sequela in patients with pituitary or brain tumors or in patients with a history of traumatic brain injury or cranial irradiation. In addition, approximately one third of children who were diagnosed with GH deficiency will remain GH deficient as adults. Since AGHD is characterized by diminished cardiovascular health, abnormal body composition, decreased muscle strength and aerobic capacity, poor quality of life, and increased mortality, i...

Background: Growth hormone deficiency (GHD) is a rare disorder characterized by pronounced and symptomatic hypo secretion of growth hormone (GH) from the anterior pituitary gland. Biochemical tests are used as part of the diagnosis in both children and adults but controversies remain as regards whom, when, and how to test, and also how to interpret a given biochemical test result.Aim: To map the current clinical practice of GHD diagnosing in children and...

Introduction: Growth hormone (GH) replacement therapy is safe and confers significant benefits in body composition, bone health, cardiometabolic risk factors, and quality of life in adults with GH deficiency. However, longer term safety and efficacy data are limited by the lack of consistency in data collection between studies. The study aim was to develop a simple global register by standardising and developing a minimum data set (MDS) to facilitate international collection o...